Invasive Infections of Aggregatibacter (Actinobacillus) Actinomycetemcomitans
نویسندگان
چکیده
منابع مشابه
Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron.
The gram-negative oral and systemic pathogen Aggregatibacter (Actinobacillus) actinomycetemcomitans produces a leukotoxin (LtxA) that is a member of the RTX (repeats in toxin) family of secreted bacterial toxins. We have recently shown that LtxA has the ability to lyse erythrocytes, which results in a beta-hemolytic phenotype on Columbia blood agar. To determine if LtxA is regulated by iron, we...
متن کاملAzithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.
Aggregatibacter actinomycetemcomitans invades periodontal pocket epithelium and is therefore difficult to eliminate by periodontal scaling and root planing. It is susceptible to azithromycin, which is taken up by many types of mammalian cells. This led us to hypothesize that azithromycin accumulation by gingival epithelium could enhance the killing of intraepithelial A. actinomycetemcomitans. [...
متن کاملAzithromycin Kills Invasive Aggregatibacter actinomycetemcomitans in Gingival Epithelial
Address correspondence to: 8 John D. Walters 9 College of Dentistry, The Ohio State University 10 305 West 12th Avenue 11 Columbus, OH 43210 12 Telephone: (614) 292-1169 13 Fax: (614) 292-2438 14 email: [email protected] 15 16 Running Title: Azithromycin Kills Intra-epithelial Aggregatibacter 17
متن کاملDiminished treatment response of periodontally diseased patients infected with the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans.
This longitudinal study evaluated the response to periodontal treatment by subjects infected with either JP2 (n = 25) or non-JP2 (n = 25) Aggregatibacter (Actinobacillus) actinomycetemcomitans. Participants were treated during the first 4 months by receiving (i) scaling and root planing, (ii) systemic antibiotic therapy, and (iii) periodontal surgery. Probing depth (PD), clinical attachment lev...
متن کاملDifferential interaction of Aggregatibacter (Actinobacillus) actinomycetemcomitans LsrB and RbsB proteins with autoinducer 2.
Our previous studies showed that the Aggregatibacter actinomycetemcomitans RbsB protein interacts with cognate and heterologous autoinducer 2 (AI-2) signals and suggested that the rbsDABCK operon encodes a transporter that may internalize AI-2 (D. James et al., Infect. Immun. 74:4021-4029, 2006.). However, A. actinomycetemcomitans also possesses genes related to the lsr operon of Salmonella ent...
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ژورنال
عنوان ژورنال: Journal of Microbiology, Immunology and Infection
سال: 2010
ISSN: 1684-1182
DOI: 10.1016/s1684-1182(10)60076-x